Searchable abstracts of presentations at key conferences in endocrinology

ea0028p370 | Thyroid | SFEBES2012

Acute bulbar palsy in association with Graves thyrotoxicosis

Abbara Ali , Chhina Navpreet , Joharatnam Jalini , Todd Jeannie , Williams Graham

A 77 year old man with a background of Crohns disease requiring ileostomy, pernicious anaemia and hypertension, presented with a 4month history of dysphagia to solids, hoarseness of voice, anorexia and marked weight loss of 30 kg. He was initially referred to gastroenterology, who performed an endoscopy which was normal. Subsequently he was referred to the ENT and speech and language therapy departments. A video fluoroscopy confirmed severe oropharyngeal dysphagia with effortf...

ea0025oc4.3 | Bone and diabetes | SFEBES2011

Rapid bone turnover responses to increased hypothalamic–pituitary–thyroid-axis activity are mediated by thyroid hormones

Gogakos Apostolos , Murphy Elaine , Bassett Duncan , Williams Graham

Increased hypothalamic–pituitary–thyroid (HPT) axis activity results in high bone turnover. T3 stimulates osteoblast and osteoclast activities, whereas TSH is proposed to inhibit bone turnover directly. Resolving the relative importance of T3 and TSH is complicated by their physiological inverse relationship. We studied 10 controls and 4 patients with resistance to thyroid hormone (RTH), in which mutation of thyroid hormone receptor beta (THR...

ea0050oc6.1 | Bone, Calcium and Neoplasia | SFEBES2017

Photoperiod-induced central actions of thyroid hormone are essential for medullary bone formation

Butterfield Natalie , Miszkiewicz Justyna , Logan John , Leitch Victoria , Yoshimura Takashi , Bassett Duncan , Williams Graham

Seasonal reproduction enables animals outside tropical regions to rear offspring in a favourable environment. Increasing day length triggers a hypothalamic relay involving thyrotropin, the type 2 deiodinase enzyme and thyroid hormone, which activates the hypothalamic-pituitary-gonadal axis to induce reproductive competence. Photoperiod regulates calcium metabolism and the egg-laying cycle in the Japanese quail (Coturnix japonica), and we hypothesised that activity of ...

ea0050oc6.1 | Bone, Calcium and Neoplasia | SFEBES2017

Photoperiod-induced central actions of thyroid hormone are essential for medullary bone formation

Butterfield Natalie , Miszkiewicz Justyna , Logan John , Leitch Victoria , Yoshimura Takashi , Bassett Duncan , Williams Graham

Seasonal reproduction enables animals outside tropical regions to rear offspring in a favourable environment. Increasing day length triggers a hypothalamic relay involving thyrotropin, the type 2 deiodinase enzyme and thyroid hormone, which activates the hypothalamic-pituitary-gonadal axis to induce reproductive competence. Photoperiod regulates calcium metabolism and the egg-laying cycle in the Japanese quail (Coturnix japonica), and we hypothesised that activity of ...

ea0025p339 | Thyroid | SFEBES2011

Thyroid hormone receptor alpha is a permissive factor that regulates osteoclastogenesis indirectly

Nicholls Jonathan J , Combs Charlotte E , Williams Graham R , Bassett J H Duncan

Thyrotoxicosis is characterised by increased osteoclast activity. Thyroid hormone receptor alpha (TRα) is the predominant TR-isoform in bone and mice lacking TRα have skeletal hypothyroidism with impaired osteoclastic bone resorption. By contrast, mice lacking TRβ have skeletal hyperthyroidism and increased bone resorption. Thus, we hypothesized that T3 acts via TRα to stimulate osteoclastogenesis. Osteoclasts were differentiated in vitro ...

ea0021oc4.2 | Bone and parathyroid | SFEBES2009

Intra-cellular availability of T3 in chondrocytes is essential for normal skeletal development and adult bone mass

Bernstein Nicholas , Archanco Marta , Swinhoe Rowan , Lu Yan , Hernandez Rebecca , Bassett Duncan , Williams Graham

The type 3 deiodinase enzyme (D3) inactivates T3 and prevents activation of T4 to protect the fetus from premature exposure to thyroid hormones. Rapidly falling levels of D3 activity and rising levels of T3 at birth initiate the onset of cell differentiation and organ maturation during the post-natal period. Congenital hypothyroidism causes delayed ossification with reduced bone mineral deposition and short stature. We hypothesize that increase...

ea0021oc4.6 | Bone and parathyroid | SFEBES2009

Impaired osteoblast function in mice lacking the T3-responsive calcineurin inhibitor RCAN2

Bassett Duncan , Boyde Alan , Howell Peter , Sun Xiao-Yang , Xu Sai , Murata Yoshiharu , Williams Graham

Similar to thyroid hormones, the calcineurin/NFAT pathway regulates bone mass via its actions in osteoblasts and by indirect effects on osteoclast function. Calcineurin is a calcium- and calmodulin-activated phosphatase that dephosphorylates the transcription factor NFAT enabling its translocation to the nucleus. RCAN2 is an inhibitor of calcineurin that is stimulated by T3 in brain, heart and skeletal muscle although its expression in bone has not been studied. Thu...

ea0021p219 | Endocrine tumours and neoplasia | SFEBES2009

MEN2B patients with a RET A883F mutation have less aggressive MTC than those with the common RET M918T mutation

Worth Gabriella , Palazzo Fausto , Tolley Neil , Robinson Stephen , Cox Jeremy , Williams Graham , Bassett Duncan

MEN2B is the most aggressive form of MEN2. Consequently, the new American Thyroid Association guidelines recommend prophylactic thyroidectomy early in the first year of life. Ninety-seven percentage of MEN2B cases result from a germline methionine to threonine mutation at codon 918 (M918T) of the RET proto-oncogene. In addition, an exceedingly rare alanine to phenylalanine mutation at codon 883 (A883F) has been reported in 4 unrelated adults. In each case metastatic MTC and th...

ea0025oc1.1 | Young Endocrinologists prize session | SFEBES2011

Thyroid hormones in the euthyroid range predict subsequent body mass composition in women: the OPUS study

Rao Preethi , Williams Graham , Murphy Elaine , Reid David , Roux Christian , Felsenberg Dieter , Gluer Claus , Eastell Richard , Razvi Salman

Background: Thyroid disease is associated with BMI with hyperthyroidism causing weight loss and hypothyroidism leading to weight gain. However, the relation of body weight distribution to thyroid function in euthyroid individuals is unclear. This study assessed body composition in euthyroid women.Methods: Euthyroid women (n=1072) from the Osteoporosis and Ultrasound Study (OPUS), a population based cohort study recruited participants from 5 Europe...

ea0025p154 | Diabetes, metabolism and cardiovascular | SFEBES2011

Over-expression of iodothyronine deiodinase III in the hypothalamic VMN as a potential model of local hypothyroidism

Greenwood Hannah , Counsell John , Richardson Errol , Dhillo Waljit , Boelen Anita , Williams Graham , Bassett Duncan , Bloom Steve , Gardiner James

The hypothalamo-pituitary–thyroid (HPT) axis maintains controlled systemic levels of thyroid hormone (TH). This is achieved through negative feedback via the hypothalamic arcuate and paraventricular nuclei. The effects of thyroid hormone in other hypothalamic nuclei are yet to be elucidated. Administration of triiodothyronine (T3, thyroid hormone) into the hypothalamic ventromedial nucleus (VMN) increases food intake in rats. Thyroid hormone activation and inac...